High Quality Pharmaceutical Intermediate Medicine 98% Antimalarial Powder CAS 88495-63-0 Artesunate
| Product Name |
High Quality Pharmaceutical Intermediate Medicine 98% Antimalarial Powder CAS 88495-63-0 Artesunate |
| Appearance |
White powder |
| Molecular formula |
C19h28o8 |
| Molecular Weight |
384.42 |
| Keywords |
Medicine Artesunate;Powder Artesunate;Artesunate Antimalarial |
| Shelf Life |
24 months when properly stored |
| Storage |
Keep in a cool, dry, dark location |
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What is artesunate ?
Artesunate is used primarily as treatment for malaria; it has also been shown to be >90% efficacious at reducing egg production in Schistosoma haematobium infection. According to WHO intravenous AS is the drug of choice for severe malaria both in children and adults where there is low transmission.In regions where transmission is high, randomized trials among Asian adults and African children strongly advocates the use of artesunate over as the treatment of choice for falciparum malaria. Artesunate is prepared from dihydroartemisinin (DHA) by reacting it with succinic acid anhydride in basic medium. As base/solvent, sodium bicarbonate and catalyst DMAP have been used, with yields of up to 100%. A large scale process involves treatment of DHA with a mixture, a catalytic amount of DMAP and succinic anhydride. The mixture is stirred for 6-9 h to get artesunate in quantitative yield. The product is further re-crystallized. alpha-Artesunate is exclusively formed (m.p 135-137C)..
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Function of artesunate
Artesunate is an antimalarial agent. It is a water-soluble hemisuccinate derivative of dihydroartemisinin.
Artemisinin is a sesquiterpene lactone isolated from Artemisia annua, a herb that has traditionally been used in China for the treatment of malaria.
Artesunate and its active metabolite dihydroartemisinin are potent blood schizonticides, active against the ring stage of the parasite.
Artesunate is ideal for the treatment of severe malaria, including cerebral malaria. It is also active against chloroquine and mefloquine resistant strains of P. falciparum. It is unstable in neutral solution and is therefore only available for injections as artesunic acid.. .
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Application of artesunate
1. With function of controlling of vivax malaria and falciparum malaria symptom, as well as treatment of chloroquine-resistant strain of insect.
2. With function of oxidant. artemisinin is reduced by catalase,dithiothreitol and alpha tocopherol.
3. With the function of antibacterial, artemisinin has anti-influenza virus effect.
4. With the function of anti-parasite, artemisinin on the role of anti-schistosomiasis and leptospirosis. .
Pharmaceutical Intermediates Antimalarial Antiparasitic Drug CAS 8495-63-0 Artesunate Powder
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Xi'an International Healthcare Factory Co., Ltd., was established in May 2010,and located in Gaoling Industrial
Park, Xi'an city, Shaanxi Province, China. It is a professional supplier of veterinary medicine, pharmaceutical ,raw material
,Vertinary drug ,medicine,Plant Extractand natural active ingredients It has absolute advantage because of strong
research strength, modern management system and high-quality marketing team.
Now we have 3 GMP standard workshop, Meanwhile, the factory is equipped with the researching and quality inspection
centre, with strong technology research and development strength. We also have 3 sales departments over 30 people and
sell our products all over the world.
For customer's needs, OEM service is also acceptable. If you have a good idea in new product production but lack of
laboratory device and human resource, we are glad to solve this problem for you. Sincerely hope to strengthen exchanges
and cooperation with friends from both home and abroad.
Q: What's your MOQ ?
A: For the high value product, our MOQ starts from 1g and generally starts from 10gs. For other low, price product, our MOQ starts from 100g and 1kg.
Q: Is there a discount ?
A: Yes, for larger quantity, we always support with better price.
Q: How to confirm the Product Quality before placing orders ?
A: You can get free samples for some proucts, you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests, we will manufacture the products according to your requests.
Q: How to start orders or make payments ?
A: You can send our your Purchase order ( if your company has ), or just send a simple confirmation by email or by Trade Manager, and we will send you Proforma Invoice with our bank details for your confirmation, then you can make payment accordingly.
Q: How do you treat quality complaint ?
A: First of all, our quality control will reduce the quality problem to near zero. If there is a quality problem caused by us, we will send you free goods for replacement or refund your loss.
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