Best Price Lcz696 Powder CAS 936623-90-4 Lcz696 for Treatment of Heart Failure

• Powder: Yes
• Customized: Customized
• Certification: GMP, HSE, ISO 9001, USP, BP
• Suitable for: Adult
• State: Powder
• Purity: >99%
• Model NO.: IHF-Lcz696
• Product Name: Lcz696
• Certificate: GMP ISO USP Bp
• Assay: 99% Min
• Test: HPLC
• CAS: 936623-90-4
• Mf: C48h58n6o8
• MW: 847.03
• Active Ingredient: Lcz696
• Sample: Lcz696 Avaliable
• Type of Product: Auxiliaries and Other Medicinal Chemicals
• Storage: Cool Dry Place
• Keywords: Lcz696 Powder
• Place of Origin: China
• Typei: Flavor & Fragrance Intermediates
• Stater: Powder
• Transport Package: 1kg Per Foil Bag, 10 Bags Per Carton. 25 Kg Per Dr
• Specification: 99% min
• Trademark: Inter-Health
• Origin: Shaanxi China
• Production Capacity: 500000kg/Year

Product Description

Best Price Lcz696 Powder CAS 936623-90-4 Lcz696 for Treatment of Heart Failure

Product name	Best Price Lcz696 Powder CAS 936623-90-4 Lcz696 for Treatment of Heart Failure
Appearance	White powder
Molecular formula	C48H58N6O8
Keywords	Lcz696;Lcz696 Powder;Lcz696  CAS 936623-90-4
Shelf Life	24 months when properly stored
Storage	Keep in a cool, dry, dark location

 

What is LCZ696? LCZ696 is a dual angiotensin II receptor antagonist and neprilysin inhibitor that is a combination of the nonpeptide angiotensin II receptor antagonist valsartan (Item No. 14178) and AHU377 (Item No. 21473), a prodrug of LBQ657 (Item No. 19829), which is an inhibitor of the zinc metallopeptidase neprilysin., LCZ696 (2-60 mg) induces a dose-dependent decrease in mean arterial pressure in rats expressing human renin and angiotensinogen, a double-transgenic model for angiotensin II-dependent hypertension. Formulations containing LCZ696 are under clinical investigation for the treatment of mild to moderate hypertension and chronic heart failure.

 

Function of LCZ696

LCZ696 is a dual angiotensin II receptor antagonist and neprilysin inhibitor that is a combination of the nonpeptide angiotensin II receptor antagonist valsartan (Item No. 14178) and AHU377 (Item No. 21473), a prodrug of LBQ657 (Item No. 19829), which is an inhibitor of the zinc metallopeptidase neprilysin., LCZ696 (2-60 mg) induces a dose-dependent decrease in mean arterial pressure in rats expressing human renin and angiotensinogen, a double-transgenic model for angiotensin II-dependent hypertension. Formulations containing LCZ696 are under clinical investigation for the treatment of mild to moderate hypertension and chronic heart failure.
Application of LCZ696

LCZ696 a drug developed by Novartis Pharmaceutical of the United States for the treatment of heart failure. Heart failure is a life-threatening disease. The patient's heart cannot pump enough blood to supply the body, and appear the symptoms of dyspnea, fatigue and fluid retention slowly, then gradually increased, significantly affect the quality of life.
LCZ696 is a dual-acting angiotensin-receptor enkephalinase inhibitor that has a unique mechanism that is thought to reduce the strain of failing hearts. LCZ696 can enhance the body's natural defense against heart failure, as well as increase the level of natriuretic peptides and other endogenous vasoactive peptides, and inhibit the renin-angiotensin-aldosterone system (RAAS). LCZ696 has combined with Novartis's Hypertension Medication (Diovan, generic name: valsartan) and the experimental drug AHU-377. AHU377 blocks the mechanism of the two peptides responsible for lowering blood pressure. Diovan improves vasodilatation and stimulates the body to excrete sodium and water.
The safety threshold of cardiovascular drugs is extremely high, and LCZ696 even shows a higher safety than conventional drugs. Previously, Novartis vigorously develop the cardiovascular drug- serelaxi, while because of security issues, both the FDA and the European Union did

 

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Q: What's your MOQ ?

A: For the high value product, our MOQ starts from 1g and generally starts from 10gs. For other low, price product, our MOQ starts from 100g and 1kg.

 

Q: Is there a discount ?

A: Yes, for larger quantity, we always support with better price.

 

Q: How to confirm the Product Quality before placing orders ?

A: You can get free samples for some proucts, you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests, we will manufacture the products according to your requests.

 

Q: How to start orders or make payments ?

A: You can send our your Purchase order ( if your company has ), or just send a simple confirmation by email or by Trade Manager, and we will send you Proforma Invoice with our bank details for your confirmation, then you can make payment accordingly.

 

Q: How do you treat quality complaint ?

A: First of all, our quality control will reduce the quality problem to near zero. If there is a quality problem caused by us, we will send you free goods for replacement or refund your loss.