High Purity Pharmaceutical 99% Raw Material Valrubicin Powder CAS 56124-62-0 Valrubicin

• Product Name: Valrubicin
• Certificate: GMP ISO USP Bp
• Assay: 99% Min
• Test: HPLC
• CAS: 56124-62-0
• Mf: C34h36f3no13
• Model NO.: IHF-Valrubicin
• Active Ingredient: Valrubicin
• Sample: Valrubicin Avaliable
• Grade Standard: Medicine Grade
• Application: API Raw Materials
• Type of Product: Auxiliaries and Other Medicinal Chemicals
• Storage: Cool Dry Place
• Shelf Life: 2 Years Proper Storage
• Keywords: Valrubicin Powder
• MOQ: 1kg
• Transport Package: 1kg Per Foil Bag, 10 Bags Per Carton. 25 Kg Per Dr
• Specification: 99% min
• Trademark: Inter-Health
• Origin: Shaanxi China
• Production Capacity: 500000kg/Year

Product Description

High Purity Pharmaceutical 99% Raw Material Valrubicin Powder CAS 56124-62-0 Valrubicin 

Product Name	High Purity Pharmaceutical 99% Raw Material Valrubicin Powder CAS 56124-62-0 Valrubicin
Appearance	White powder
CAS	56124-62-0
Assay	99%
Keywords	Valrubicin;Valrubicin Powder;Valrubicin CAS 56124-62-0
Shelf Life	24 months when properly stored
Storage	Keep in a cool, dry, dark location

 

What is Valrubicin ?  Valrubicin is a chemotherapy drug used to treat bladder cancer.

Function of Valrubicin 

Valrubicin was launched as a new 'chemotherapeutic agent for the treatment of bladder cancer, particularly in patients with BCG-refractory carcinoma in situ (CIS) of the bladder for whom immediate cystectomy is unacceptable. It belongs to the class of anthracyclines, the widest used in human cancers, and is a N-trifluoroacetyl 14-valerate derivative of doxorubicin.

Valrubicin can be obtained in 3 steps from daunomycin by N-trifluoroacetylation of the sugar moiety then iodination of the 2-acetyl group and introduction of a valerate residue. A proposed mechanism involved in the cytotoxicity of Valrubicin coud be the blockade of SV40 large T antigen helicase; this cellular enzyme is involved in the formation of a ternary complex with DNA to maintain the topographic structure of DNA during transcription.

Application of Valrubicin 

In patients with CIS of bladder refractory to front line and second line therapies, intravesical instillation of Valrubicin resulted in a complete response with a significant rate and allowed a delay in cystectomy. Systemic absorption was minimal and accordingly produced a lower incidence of cardiotoxicity compared with doxorubicin.

Valrubicin is available in 200-mg vials for intravesicular administrationin the treatment of bladder cancer (orphan drugstatus). The increased lipophilicity associated with the valericacid ester and trifluoro acetate functionalities increasestissue penetration and remains intact because, in large measure,of the lack of exposure to hydrolyzing enzymes causedby direct delivery into the bladder followed by voiding ofthe instilled solution. This local action also minimizes cardiotoxicityand other adverse effects seen with other anthracyclines.The major adverse effects that are seen are bladderirritation and reddening of the urine.

Pharmaceutical 99% Raw Material powder CAS 56124-62-0 Valrubicin 

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Q: What's your MOQ ?

A: For the high value product, our MOQ starts from 1g and generally starts from 10gs. For other low, price product, our MOQ starts from 100g and 1kg.

 

Q: Is there a discount ?

A: Yes, for larger quantity, we always support with better price.

 

Q: How to confirm the Product Quality before placing orders ?

A: You can get free samples for some proucts, you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests, we will manufacture the products according to your requests.

 

Q: How to start orders or make payments ?

A: You can send our your Purchase order ( if your company has ), or just send a simple confirmation by email or by Trade Manager, and we will send you Proforma Invoice with our bank details for your confirmation, then you can make payment accordingly.

 

Q: How do you treat quality complaint ?

A: First of all, our quality control will reduce the quality problem to near zero. If there is a quality problem caused by us, we will send you free goods for replacement or refund your loss.