Hot Sale Pharmaceutical 99% Purity Nootropics Raw Gts-21 Powder CAS 148372-04-7 Gts-21
| Product Name |
Hot Sale Pharmaceutical 99% Purity Nootropics Raw Gts-21 Powder CAS 148372-04-7 Gts-21 |
| Appearance |
White powder |
| Molecular formula |
C19H20N2O2 |
| Molecular Weight |
308.37 |
| Keywords |
Raw Powder Gts-21;Gts-21 Powder;Gts-21 Nootropics |
| Shelf Life |
24 months when properly stored |
| Storage |
Keep in a cool, dry, dark location |
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What is GTS-21?
GTS-21 dihydrochloride is a selective α7 nicotinic acetylcholine receptor agonist, has recently been established as a promising treatment for inflammation. Target: nAChRin vitro: GTS-21 is one of the most potent α7nAChR agonists, has been reported to attenuate pro-inflammatory cytokine production, improve outcomes in sepsis models, pancreatitis, and ischemia-reperfusion injury, and inhibit the production of endotoxin-induced TNF in lung tissue. In addition, recent studies have demonstrated that GTS-21 inhibits the activities of endothelial cells and monocyte macrophages, as well as the secretion of pro-inflammatory cytokines in peripheral blood samples, by regulating the JAK2-STAT3 pathway. [1] in vivo: In septic animals, GTS-21 significantly ameliorated GI motility, lowered systemic and colonic levels of IL-6, decreased colonic permeability, and decreased the number of positive cultures obtained from blood and mesenteric lymph nodes. Splenectomy prevented animals from developing sepsis-induced ileus. Chrna7 mice displayed a more severe septic phenotype, whereas GTS-21 remarkably was also beneficial in these animals...
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Function of GTS-21
Nootropics also referred to as smart drugs, memory enhancers, neuro enhancers, cognitive enhancers, and intelligence enhancers, are drugs, supplements, nutraceuticals, and functional foods that purportedly improve mental functions such as cognition, memory, intelligence, motivation, attention, and concentration. Nootropics are thought to work by altering the availability of the brain's supply of neurochemicals (neurotransmitters, enzymes, andhormones), by improving the brain's oxygen supply, or by stimulating nerve growth...
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Application of GTS-21
GTS-21 has a high affinity for the rodent α7nAChR but its affinity for human α7nAChR is described to be low. Its metabolite, 4OH-(GTS-21) has been described to be a selective partial agonist with greater efficacy for both human and rat α7nAChRs (Conejero-Goldberg et al., 2008, Kem, 2000).
Both GTS-21 itself and its demethylated active metabolite 4-OH-GTS-21[3] display nootropic[4] and neuroprotective effects, and GTS-21 is being investigated for the treatment of Alzheimer's disease,nicotine dependence,and, most significantly, for schizophrenia ..
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Xi'an International Healthcare Factory Co., Ltd., was established in May 2010,and located in Gaoling Industrial
Park, Xi'an city, Shaanxi Province, China. It is a professional supplier of veterinary medicine, pharmaceutical ,raw material
,Vertinary drug ,medicine,Plant Extractand natural active ingredients It has absolute advantage because of strong
research strength, modern management system and high-quality marketing team.
Now we have 3 GMP standard workshop, Meanwhile, the factory is equipped with the researching and quality inspection
centre, with strong technology research and development strength. We also have 3 sales departments over 30 people and
sell our products all over the world.
For customer's needs, OEM service is also acceptable. If you have a good idea in new product production but lack of
laboratory device and human resource, we are glad to solve this problem for you. Sincerely hope to strengthen exchanges
and cooperation with friends from both home and abroad.
Q: What's your MOQ ?
A: For the high value product, our MOQ starts from 1g and generally starts from 10gs. For other low, price product, our MOQ starts from 100g and 1kg.
Q: Is there a discount ?
A: Yes, for larger quantity, we always support with better price.
Q: How to confirm the Product Quality before placing orders ?
A: You can get free samples for some proucts, you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests, we will manufacture the products according to your requests.
Q: How to start orders or make payments ?
A: You can send our your Purchase order ( if your company has ), or just send a simple confirmation by email or by Trade Manager, and we will send you Proforma Invoice with our bank details for your confirmation, then you can make payment accordingly.
Q: How do you treat quality complaint ?
A: First of all, our quality control will reduce the quality problem to near zero. If there is a quality problem caused by us, we will send you free goods for replacement or refund your loss.
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